An all-new Holden Commodore chassis, known as the VE was unveiled in July 2006. Following this, a new range of “E” Series HSV models were released in August 2006. Changes to the exhaust system yielded a 10kw increase in power for the LS2 to 307kw. Extensive modifications to the base VE Commodore sheetmetal and interior were introduced, most notably the unique LED taillights and distinctive side vents. The new GM 6L80-E 6 speed automatic transmission from the VE Commodore is offered, and Electronic Stability Control is standard on all models.

The result was a total of 301 end-to-end exclusive HSV modifications, including the 307kW of power output, 550Nm of torque (series 1), a sports-tuned Electronic Stability Control system and the revolutionary Magnetic Ride Control suspension technology.

E Series 3 launched in September 2010, Holden Special Vehicles released the E Series 3, the last version of the E Series. The noticeable changes between E Series 2 and 3 include the GTS power has been increased to 325 kW, making it once again the top of the HSV list with the rest of the range powered by a 317kw LS3 V8. The new engines have also improved fuel economy by 4.2 per cent on the LS3 V8. An all new interior across the range and the introduction of a range of new technologies including an Enhanced Driver Interface, Liquid Propane Injection and Side Blind Zone Alert.